Upcoming Live Webinars

Light scattering solutions for multi-attribute quantification of mRNA-lipid nanoparticle therapeutics

Join us for a webinar on Tuesday, May 7th at 8:00 AM PDT | 11:00 AM EDT | 17:00 CET

Light scattering techniques deliver multi-attribute quantification (MAQ) of mRNA and lipid nanoparticle-formulated mRNA, and can play a key role in product and process development as well as quality control of mRNA-LNP therapeutics. Specifically, multi-angle light scattering (MALS) coupled to separation by field-flow fractionation (FFF) or size-exclusion chromatography (SEC) provides high-resolution quantification of several mRNA and LNP attributes including size distribution, physical stability, LNP number concentration, morphology, and mRNA and lipid concentration. The method can also be applied to evaluate how these attributes are affected by preparation, formulation, and storage conditions. In addition to high-resolution MAQ by SEC/FFF-MALS, dynamic light scattering (DLS) and electrophoretic light scattering (ELS) can be used for rapid, automatable batch measurements of particle size and concentration, polydispersity, and zeta potential, enabling rapid screening of the impact of different ions, ionic strength, pH, temperature and other parameters on the biophysical properties and stability of mRNA and LNP-mRNA.

An Orthogonal Approach for Comprehensive AAV Characterization

Join us for a webinar on Thursday, May 30th at 8:00 AM PDT | 11:00 AM EDT | 17:00 CET

As the field of gene therapy progresses, processes to produce this life-changing therapy may introduce impurities that can significantly impact its performance and quality. Notably, empty AAV capsids represent a critical product-related impurity, necessitating accurate analytical methods to measure their levels. Our webinar will delve into the development and optimization of a size exclusion chromatography with UV and multiangle light scattering (SEC-MALS). We will also explore the full-to-empty ratio as well as the quantification of partials using charge detection mass spectrometry (CDMS). Join us to learn more about how SEC-MALS and CDMS can revolutionize analytical development and quality control testing. Additionally, discover how the standard AAV Method Implementation and Training Service, as well as SOP Guidance Manual, can facilitate the adoption of advanced technology as a platform method for AAV development and production.

Application of SEC-MALS-QELS in the Development of Recombinant Protein-Based Malaria Vaccines

Join us for a webinar on Tuesday, June 4th at 8:00 AM PDT | 11:00 AM EDT | 17:00 CET

This seminar addresses cutting-edge strategies targeting multiple stages of the Plasmodium parasite lifecycle in mosquitoes and how conjugating poorly immunogenic molecules with potent carriers can revolutionize malaria vaccine development. Malaria eradication efforts rely on innovative approaches like transmission-blocking vaccines (TBVs). This study from Dr. David Narum at the NIH, examines human antibodies produced in response to vaccine candidates and how tailored development of vaccines are critical for effectively combating diseases like malaria.