Upcoming Live Webinars

An Orthogonal Approach for Comprehensive AAV Characterization

Join us for a webinar on Thursday, May 30th at 8:00 AM PDT | 11:00 AM EDT | 17:00 CET

As the field of gene therapy progresses, processes to produce this life-changing therapy may introduce impurities that can significantly impact its performance and quality. Notably, empty AAV capsids represent a critical product-related impurity, necessitating accurate analytical methods to measure their levels. Our webinar will delve into the development and optimization of a size exclusion chromatography with UV and multiangle light scattering (SEC-MALS). We will also explore the full-to-empty ratio as well as the quantification of partials using charge detection mass spectrometry (CDMS). Join us to learn more about how SEC-MALS and CDMS can revolutionize analytical development and quality control testing. Additionally, discover how the standard AAV Method Implementation and Training Service, as well as SOP Guidance Manual, can facilitate the adoption of advanced technology as a platform method for AAV development and production.

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Insights into mRNA Lipid Nanoparticle Polydispersity and Shape of Using Quantitative Solution Biophysics

Join us for a webinar on Thursday, June 20th at 8:00 AM PDT | 11:00 AM EDT | 17:00 CET

Lipid nanoparticles (LNPs) are crucial for RNA therapeutics, notably after the success of Patisiran and COVID-19 mRNA vaccines. LNPs need precise design for effective clinical use, but the understanding on mixing methods influences the LNP structure and biological activity is limited.

This study addresses this gap by comparing standard and advanced characterization methods including multi-wavelength analytical ultracentrifugation (MWL-AUC), multi-angle light scattering (MALS), and synchrotron size-exclusion chromatography small-angle X-ray scattering (SEC-SAXS) with singular-value decomposition methods (SVD). We analyze LNPs from two production methods: microfluidic rapid mixing and bulk mixing. The characterization techniques employed here can enhance our understanding of LNP structure-function relationships and enable researchers to define their RNA LNP products more precisely, which can improve LNP quality and potentially accelerate pharmaceutical development.

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Recent Webinars

Previous webinars may be viewed in our Webinar Library. The following recent webinars are now available:

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